Stanford University researchers are enrolling participants in a pioneering study investigating the feasibility of allowing people with paralysis to use a technology that interfaces directly with the brain to control computer cursors, robotic arms and other assistive devices. Those eligible to enroll in the trial include people with weakness of all four limbs resulting from cervical spinal cord injury, brainstem stroke, muscular dystrophy, or motor neuron disease, such as amyotrophic lateral sclerosis (Lou Gehrig's disease). The pilot clinical trial, known as BrainGate2,* is based on technology developed at Brown University and is led by researchers at Massachusetts General Hospital, Brown and the Providence Veterans Affairs Medical Center. The researchers have now invited the Stanford team to establish the only trial site outside of New England. Under development since 2002, BrainGate is a combination of hardware and software that directly senses electrical signals in the brain that control movement.